Basic Principles of MLC
Author
Source
Chromatography Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Micellar liquid chromatography (MLC) is an efficient alternative to conventional reversed-phase liquid chromatography with hydro-organic mobile phases.
Almost three decades of experience have resulted in an increasing production of analytical applications.
Current concern about the environment also reveals MLC as an interesting technique for “green” chemistry because it uses mobile phases containing 90% or more water.
These micellar mobile phases have a low toxicity and are not producing hazardous wastes.
The stationary phase is modified with an approximately constant amount of surfactant monomers, and the solubilising capability of the mobile phase is altered by the presence of micelles, giving rise to a great variety of interactions (hydrophobic, ionic, and steric) with major implications in retention and selectivity.
From its beginnings in 1980, the technique has evolved up to becoming in a real alternative in some instances (and a complement in others) to classical RPLC with aqueous-organic mixtures, owing to its peculiar features and unique advantages.
The addition of an organic solvent to the mobile phase was, however, soon suggested in order to enhance the low efficiencies and weak elution strength associated with the mobile phases that contained only micelles.
American Psychological Association (APA)
Rambla-Alegre, Maria. 2012. Basic Principles of MLC. Chromatography Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506480
Modern Language Association (MLA)
Rambla-Alegre, Maria. Basic Principles of MLC. Chromatography Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-506480
American Medical Association (AMA)
Rambla-Alegre, Maria. Basic Principles of MLC. Chromatography Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506480