Trichinella spiralis Excretory-Secretory Products Protect against Polymicrobial Sepsis by Suppressing MyD88 via Mannose Receptor
Joint Authors
Yu, Yang
Li, Leiqing
Liu, Lihua
Du, Linlin
Shan, Hui
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Trichinella spiralis (T.
spiralis) or its excretory-secretory products (TsES) protect hosts from autoimmune diseases, which depend on inducing host T helper (Th) 2 immune response and inhibiting inflammatory factors.
Sepsis is a systemic inflammatory response syndrome (SIRS) evoked by infection.
Little is known about the effects of helminths or their excretory-secretory products on sepsis.
Here, we investigated the effects of TsES in a mice model of polymicrobial sepsis.
TsES improved survival, reduced organ injury, and enhanced bacterial clearance in septic mice.
To investigate the molecular mechanism, macrophages from septic patients or the control group were incubated with TsES.
TsES reduced sepsis-inducing inflammatory cytokines mediated by Toll-like receptors (TLR) in vitro by suppressing TLR adaptor-transducer myeloid differentiation factor 88 (MyD88) and nuclear factor- (NF-)-κB.
Furthermore, TsES upregulated mannose receptor (MR) expression during sepsis.
MR blocking attenuated the effects of TsES on MyD88 and NF-κB expression.
In vivo, MR RNAi reduced the survival rate of septic mice treated with TsES, suggesting that TsES-mediated protection against polymicrobial sepsis is dependent on MR.
Thus, TsES administration might be a potential therapeutic strategy for treating sepsis.
American Psychological Association (APA)
Du, Linlin& Liu, Lihua& Yu, Yang& Shan, Hui& Li, Leiqing. 2014. Trichinella spiralis Excretory-Secretory Products Protect against Polymicrobial Sepsis by Suppressing MyD88 via Mannose Receptor. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-506491
Modern Language Association (MLA)
Du, Linlin…[et al.]. Trichinella spiralis Excretory-Secretory Products Protect against Polymicrobial Sepsis by Suppressing MyD88 via Mannose Receptor. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-506491
American Medical Association (AMA)
Du, Linlin& Liu, Lihua& Yu, Yang& Shan, Hui& Li, Leiqing. Trichinella spiralis Excretory-Secretory Products Protect against Polymicrobial Sepsis by Suppressing MyD88 via Mannose Receptor. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-506491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506491