Nucleobase-Based Barbiturates : Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay
Joint Authors
Dhorajiya, Bhaveshkumar D.
Dholakiya, Bharatkumar Z.
Badria, Farid A.
Ibrahim, Ahmed S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A number of nucleobase-based barbiturates have been synthesized by combination of nucleic acid bases and heterocyclic amines and barbituric acid derivatives through green and efficient multicomponent route and one pot reaction.
This approach was accomplished efficiently using aqueous medium to give the corresponding products in high yield.
The newly synthesized compounds were characterized by spectral analysis (FT-IR, 1H NMR, 13C NMR, HMBC, and UV spectroscopy) and elemental analysis.
Representative of all synthesized compounds was tested and evaluated for antioxidant, bleomycin-dependent DNA damage, and Lymphocyte Transformation studies.
Compounds TBC > TBA > TBG showed highest lymphocyte transformation assay, TBC > TBA > BG showed inhibitory antioxidant activity using ABTS methods, and TBC > BPA > BAMT > TBA > 1, 3-TBA manifested the best protective effect against DNA damage induced by bleomycin.
American Psychological Association (APA)
Dhorajiya, Bhaveshkumar D.& Dholakiya, Bharatkumar Z.& Ibrahim, Ahmed S.& Badria, Farid A.. 2014. Nucleobase-Based Barbiturates : Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506493
Modern Language Association (MLA)
Dhorajiya, Bhaveshkumar D.…[et al.]. Nucleobase-Based Barbiturates : Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-506493
American Medical Association (AMA)
Dhorajiya, Bhaveshkumar D.& Dholakiya, Bharatkumar Z.& Ibrahim, Ahmed S.& Badria, Farid A.. Nucleobase-Based Barbiturates : Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506493
