Lipofundin-Induced Hyperlipidemia Promotes Oxidative Stress and Atherosclerotic Lesions in New Zealand White Rabbits

Abstract EN

Atherosclerosis represents a major cause of death in the world.

It is known that Lipofundin 20% induces atherosclerotic lesions in rabbits, but its effects on serum lipids behaviour and redox environment have not been addressed.

In this study, New Zealand rabbits were treated with 2 mL/kg of Lipofundin for 8 days.

Then, redox biomarkers and serum lipids were determined spectrophotometrically.

On the other hand, the development of atherosclerotic lesions was confirmed by eosin/hematoxylin staining and electron microscopy.

At the end of the experiment, total cholesterol, triglycerides, cholesterol-LDL, and cholesterol-HDL levels were significantly increased.

Also, a high index of biomolecules damage, a disruption of both enzymatic and nonenzymatic defenses, and a reduction of nitric oxide were observed.

Our data demonstrated that Lipofundin 20% induces hyperlipidemia, which promotes an oxidative stress state.

Due to the importance of these phenomena as risk factors for atherogenesis, we suggest that Lipofundin induces atherosclerosis mainly through these mechanisms.