Synthesis and Characterization of Poly(lactic-co-glycolic) Acid Nanoparticles-Loaded ChitosanBioactive Glass Scaffolds as a Localized Delivery System in the Bone Defects
Joint Authors
Mozafari, M.
Asgari, S.
Moztarzadeh, F.
Jalali, N.
Nazemi, K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The functionality of tissue engineering scaffolds can be enhanced by localized delivery of appropriate biological macromolecules incorporated within biodegradable nanoparticles.
In this research, chitosan/58S-bioactive glass (58S-BG) containing poly(lactic-co-glycolic) acid (PLGA) nanoparticles has been prepared and then characterized.
The effects of further addition of 58S-BG on the structure of scaffolds have been investigated to optimize the characteristics of the scaffolds for bone tissue engineering applications.
The results showed that the scaffolds had high porosity with open pores.
It was also shown that the porosity decreased with increasing 58S-BG content.
Furthermore, the PLGA nanoparticles were homogenously distributed within the scaffolds.
According to the obtained results, the nanocomposites could be considered as highly bioactive bone tissue engineering scaffolds with the potential of localized delivery of biological macromolecules.
American Psychological Association (APA)
Nazemi, K.& Moztarzadeh, F.& Jalali, N.& Asgari, S.& Mozafari, M.. 2014. Synthesis and Characterization of Poly(lactic-co-glycolic) Acid Nanoparticles-Loaded ChitosanBioactive Glass Scaffolds as a Localized Delivery System in the Bone Defects. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506512
Modern Language Association (MLA)
Nazemi, K.…[et al.]. Synthesis and Characterization of Poly(lactic-co-glycolic) Acid Nanoparticles-Loaded ChitosanBioactive Glass Scaffolds as a Localized Delivery System in the Bone Defects. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-506512
American Medical Association (AMA)
Nazemi, K.& Moztarzadeh, F.& Jalali, N.& Asgari, S.& Mozafari, M.. Synthesis and Characterization of Poly(lactic-co-glycolic) Acid Nanoparticles-Loaded ChitosanBioactive Glass Scaffolds as a Localized Delivery System in the Bone Defects. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506512
