The Influence of Nrf2 on Cardiac Responses to Environmental Stressors
Joint Authors
Kleeberger, Steven R.
Gladwell, Wesley
Miller-DeGraff, Laura
Cho, Hye-Youn
Devlin, Robert B.
Gougian, Eva
Myers, Page H.
Lawrence, Marcus
Cividanes, Samantha
Howden, Reuben
Rouse, D. Clay
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Nrf2 protects the lung from adverse responses to oxidants, including 100% oxygen (hyperoxia) and airborne pollutants like particulate matter (PM) exposure, but the role of Nrf2 on heart rate (HR) and heart rate variability (HRV) responses is not known.
We hypothesized that genetic disruption of Nrf2 would exacerbate murine HR and HRV responses to severe hyperoxia or moderate PM exposures.
Nrf2-/- and Nrf2+/+ mice were instrumented for continuous ECG recording to calculate HR and HRV (low frequency (LF), high frequency (HF), and total power (TP)).
Mice were then either exposed to hyperoxia for up to 72 hrs or aspirated with ultrafine PM (UF-PM).
Compared to respective controls, UF-PM induced significantly greater effects on HR (P<0.001) and HF HRV (P<0.001) in Nrf2-/- mice compared to Nrf2+/+ mice.
Nrf2-/- mice tolerated hyperoxia significantly less than Nrf2+/+ mice (~22 hrs; P<0.001).
Reductions in HR, LF, HF, and TP HRV were also significantly greater in Nrf2-/- compared to Nrf2+/+ mice (P<0.01).
Results demonstrate that Nrf2 deletion increases susceptibility to change in HR and HRV responses to environmental stressors and suggest potential therapeutic strategies to prevent cardiovascular alterations.
American Psychological Association (APA)
Howden, Reuben& Gougian, Eva& Lawrence, Marcus& Cividanes, Samantha& Gladwell, Wesley& Miller-DeGraff, Laura…[et al.]. 2013. The Influence of Nrf2 on Cardiac Responses to Environmental Stressors. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-506524
Modern Language Association (MLA)
Howden, Reuben…[et al.]. The Influence of Nrf2 on Cardiac Responses to Environmental Stressors. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-506524
American Medical Association (AMA)
Howden, Reuben& Gougian, Eva& Lawrence, Marcus& Cividanes, Samantha& Gladwell, Wesley& Miller-DeGraff, Laura…[et al.]. The Influence of Nrf2 on Cardiac Responses to Environmental Stressors. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-506524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506524