Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis
Joint Authors
Chen, Weichang
Sun, Zhandong
Sun, Shengwei
Chen, Jiajia
Wang, Shouli
Lin, Yuxin
Yan, Wenying
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Gastric cancers (GC) have the high morbidity and mortality rates worldwide and there is a need to identify sufficiently sensitive biomarkers for GC.
MicroRNAs (miRNAs) could be promising potential biomarkers for GC diagnosis.
We employed a systematic and integrative bioinformatics framework to identify GC-related microRNAs from the public microRNA and mRNA expression dataset generated by RNA-seq technology.
The performance of the 17 candidate miRNAs was evaluated by hierarchal clustering, ROC analysis, and literature mining.
Fourteen have been found to be associated with GC and three microRNAs (miR-211, let-7b, and miR-708) were for the first time reported to associate with GC and may be used for diagnostic biomarkers for GC.
American Psychological Association (APA)
Yan, Wenying& Wang, Shouli& Sun, Zhandong& Lin, Yuxin& Sun, Shengwei& Chen, Jiajia…[et al.]. 2014. Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506545
Modern Language Association (MLA)
Yan, Wenying…[et al.]. Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-506545
American Medical Association (AMA)
Yan, Wenying& Wang, Shouli& Sun, Zhandong& Lin, Yuxin& Sun, Shengwei& Chen, Jiajia…[et al.]. Identification of MicroRNAs as Potential Biomarker for Gastric Cancer by System Biological Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506545