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Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria
Joint Authors
Sonawat, Haripalsingh M.
Sengupta, Arjun
Sharma, Shobhona
Ghosh, Soumita
Basant, Angika
Source
Journal of Parasitology Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
1H NMR-based metabonomics was used to investigate the multimodal response of mice to malarial parasite infection by P.
berghei ANKA.
Liver metabolism was followed by NMR spectroscopy through the course of the disease in both male and female mice.
Our results showed alterations in the level of several metabolites as a result of the infection.
Metabolites like kynurenic acid, alanine, carnitine, and β-alanine showed significant alteration in the liver, suggesting altered kynurenic acid, glucose, fatty acid and amino acid pathways.
Distinct sexual dimorphism was also observed in the global analysis of the liver metabolic profiles.
Multiway principal component analysis (MPCA) was carried out on the liver, brain, and serum metabolic profile in order to explore the correlation of liver and brain metabolic profile to the metabolite profile of serum.
Changes in such correlation profile also indicated distinct sexual dimorphism at the early stage of the disease.
Indications are that the females are able to regulate their metabolism in the liver in such a way to maintain homeostasis in the blood.
In males, however, choline in liver showed anticorrelation to choline content of serum indicating a higher phospholipid degradation process.
The brain-serum correlation profile showed an altered energy metabolism in both the sexes.
The differential organellar responses during disease progression have implications in malaria management.
American Psychological Association (APA)
Sengupta, Arjun& Basant, Angika& Ghosh, Soumita& Sharma, Shobhona& Sonawat, Haripalsingh M.. 2011. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of Parasitology Research،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-506587
Modern Language Association (MLA)
Sengupta, Arjun…[et al.]. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of Parasitology Research No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-506587
American Medical Association (AMA)
Sengupta, Arjun& Basant, Angika& Ghosh, Soumita& Sharma, Shobhona& Sonawat, Haripalsingh M.. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of Parasitology Research. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-506587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506587