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Netrins and Their Roles in Placental Angiogenesis
Joint Authors
Alfaidy, Nadia
de Mazancourt, Philippe
Dakouane-Giudicelli, Mbarka
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules.
Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis.
In human placenta, the most vascularized organ, the presence of netrins has also been reported.
Recent studies demonstrated the involvement of netrins in the regulation of placental angiogenesis.
In this review we focused on the role of netrins in human placental angiogenesis.
Among all netrins examined, netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors.
These opposite effects appear to be related to the endothelial cell phenotype studied and seem also to depend on the receptor type to which netrin binds, that is, the canonical receptor member of the DCC family, the members of the UNC5 family, or the noncanonical receptor members of the integrin family or DSCAM.
American Psychological Association (APA)
Dakouane-Giudicelli, Mbarka& Alfaidy, Nadia& de Mazancourt, Philippe. 2014. Netrins and Their Roles in Placental Angiogenesis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506598
Modern Language Association (MLA)
Dakouane-Giudicelli, Mbarka…[et al.]. Netrins and Their Roles in Placental Angiogenesis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-506598
American Medical Association (AMA)
Dakouane-Giudicelli, Mbarka& Alfaidy, Nadia& de Mazancourt, Philippe. Netrins and Their Roles in Placental Angiogenesis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506598