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Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia
Joint Authors
Yonekura, Yutaka
Sonohata, Motoki
Ando, Yoshiki
Miyamoto, Hiroshi
Tsukamoto, Masatsugu
Eto, Shuichi
Noda, Iwao
Mawatari, Masaaki
Akiyama, Takayuki
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To reduce the incidence of implant-associated infection, we previously developed a novel coating technology using hydroxyapatite (HA) containing silver (Ag).
This study examined in vivo acute and subacute toxicity associated with the Ag-HA coating in rat tibiae.
Ten-week-old rats received implantation of HA-, 2% Ag-HA-, or 50% Ag-HA-coated titanium rods.
Concentrations of silver in serum, brain, liver, kidneys, and spleen were measured in the acute phase (2–4 days after treatment) and subacute phase (4–12 weeks after treatment).
Biochemical and histological examinations of those organs were also performed.
Mean serum silver concentration peaked in the acute phase and then gradually decreased.
Mean silver concentrations in all examined organs from the 2% Ag-HA coating groups showed no significant differences compared with the HA coating group.
No significant differences in mean levels of glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, lactate dehydrogenase, creatinine, or blood urea nitrogen were seen between the three groups and controls.
Histological examinations of all organs revealed no abnormal pathologic findings.
No acute or subacute toxicity was seen in vivo for 2% Ag-HA coating or HA coating.
Ag-HA coatings on implants may represent biologically safe antibacterial biomaterials and may be of value for reducing surgical-site infections related to implantation.
American Psychological Association (APA)
Tsukamoto, Masatsugu& Miyamoto, Hiroshi& Ando, Yoshiki& Noda, Iwao& Eto, Shuichi& Akiyama, Takayuki…[et al.]. 2014. Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506627
Modern Language Association (MLA)
Tsukamoto, Masatsugu…[et al.]. Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-506627
American Medical Association (AMA)
Tsukamoto, Masatsugu& Miyamoto, Hiroshi& Ando, Yoshiki& Noda, Iwao& Eto, Shuichi& Akiyama, Takayuki…[et al.]. Acute and Subacute Toxicity In Vivo of Thermal-Sprayed Silver Containing Hydroxyapatite Coating in Rat Tibia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506627
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506627