![](/images/graphics-bg.png)
CpG Island Methylation in Colorectal Cancer : Past, Present and Future
Joint Authors
Slattery, Martha L.
Samowitz, Wade S.
Curtin, Karen
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The concept of a CpG island methylator phenotype, or CIMP, quickly became the focus of several colorectal cancer studies describing its clinical and pathological features after its introduction in 1999 by Toyota and colleagues.
Further characterization of CIMP in tumors lead to widespread acceptance of the concept, as expressed by Shen and Issa in their 2005 editorial, “CIMP, at last.” Since that time, extensive research efforts have brought great insights into the epidemiology and prognosis of CIMP+ tumors and other epigenetic mechanisms underlying tumorigenesis.
With the advances in technology and subsequent cataloging of the human methylome in cancer and normal tissue, new directions in research to understand CIMP and its role in complex biological systems yield hope for future epigenetically based diagnostics and treatments.
American Psychological Association (APA)
Curtin, Karen& Slattery, Martha L.& Samowitz, Wade S.. 2011. CpG Island Methylation in Colorectal Cancer : Past, Present and Future. Pathology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-506661
Modern Language Association (MLA)
Curtin, Karen…[et al.]. CpG Island Methylation in Colorectal Cancer : Past, Present and Future. Pathology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-506661
American Medical Association (AMA)
Curtin, Karen& Slattery, Martha L.& Samowitz, Wade S.. CpG Island Methylation in Colorectal Cancer : Past, Present and Future. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-506661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506661