Anti-CD133 Antibody Immobilized on the Surface of Stents Enhances Endothelialization
Joint Authors
Yu, Hua
Li, Dan
Jiang, Shaoyan
Gong, Feirong
An, Yi
Li, Jian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Drug eluting stents successfully reduce restenosis at the cost of delayed reendothelialization.
In recent years, a novel concept to enhance reendothelialization using anti-CD34 antibody coated stents which capture circulating progenitor cells (EPCs) has been developed with conflicting clinical results.
CD133 is a glycoprotein expressed on circulating hematopoietic and putative endothelial-regenerating cells and may be superior to CD34 for EPCs capture stents.
In the present study, anti-CD133 antibody has been successfully immobilized to the biodegradable polymeric coating material by covalent conjugation.
We explore whether anti-CD133 antibody coated stents (CD133 stents) might accelerate reendothelialization in comparison with bare metal stents (BMS) through the superior ability to capture EPCs.
The in vitro cell culture results indicate that anti-CD133 antibody functionalized polymer film significantly promotes CD133 positive cells attachment and growth compared with the unfunctionalized polymer film.
In the semi-in vivo arteriovenous shunt model CD133 stents demonstrate much quicker specific capturing of EPCs from the blood stream than BMS within 6 hours.
In a porcine coronary artery injury model CD133 stents show more effective reendothelialization in short term compared with BMS, while no significant difference in endothelial function recovery was observed between these two groups within 6-month followup.
American Psychological Association (APA)
Li, Jian& Li, Dan& Gong, Feirong& Jiang, Shaoyan& Yu, Hua& An, Yi. 2014. Anti-CD133 Antibody Immobilized on the Surface of Stents Enhances Endothelialization. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506674
Modern Language Association (MLA)
Li, Jian…[et al.]. Anti-CD133 Antibody Immobilized on the Surface of Stents Enhances Endothelialization. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-506674
American Medical Association (AMA)
Li, Jian& Li, Dan& Gong, Feirong& Jiang, Shaoyan& Yu, Hua& An, Yi. Anti-CD133 Antibody Immobilized on the Surface of Stents Enhances Endothelialization. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506674