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The Role of Semaphorins and Their Receptors in Gliomas
Joint Authors
Law, Janice Wai Sze
Lee, Alan Yiu Wah
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Gliomas are the most common tumor in the central nervous system.
High-grade glioblastomas are characterized by their high invasiveness and resistance to radiotherapy, leading to high recurrence rate and short median survival despite radical surgical resection.
Characterizations of gliomas at molecular level have revealed aberrations of various growth factor receptors, receptor tyrosine kinases, and tumor suppressor genes that lead to deregulation of multiple signaling pathways, thereby contributing to abnormal proliferation, invasion, and resistance to apoptosis in cancer cells.
Recently, accumulating evidence points to the emerging role of axon guidance molecules in glioma progression.
Notably, many signaling events harnessed by guidance molecules to regulate cell migration and axon navigation during development are also found to be involved in the modulation of deregulated pathways in gliomas.
This paper focused on the signalings triggered by the guidance molecule semaphorins and their receptors plexins and neuropilins, and how their crosstalk with oncogenic pathways in gliomas might modulate cancer progression.
The emerging role of semaphorins and plexins as tumor suppressors or oncogenes is also discussed.
American Psychological Association (APA)
Law, Janice Wai Sze& Lee, Alan Yiu Wah. 2012. The Role of Semaphorins and Their Receptors in Gliomas. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-506687
Modern Language Association (MLA)
Law, Janice Wai Sze& Lee, Alan Yiu Wah. The Role of Semaphorins and Their Receptors in Gliomas. Journal of Signal Transduction No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-506687
American Medical Association (AMA)
Law, Janice Wai Sze& Lee, Alan Yiu Wah. The Role of Semaphorins and Their Receptors in Gliomas. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-506687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506687