Bioenergetics of Mammalian Sperm Capacitation
Joint Authors
Ferramosca, Alessandra
Zara, Vincenzo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
After ejaculation, the mammalian male gamete must undergo the capacitation process, which is a prerequisite for egg fertilization.
The bioenergetics of sperm capacitation is poorly understood despite its fundamental role in sustaining the biochemical and molecular events occurring during gamete activation.
Glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) are the two major metabolic pathways producing ATP which is the primary source of energy for spermatozoa.
Since recent data suggest that spermatozoa have the ability to use different metabolic substrates, the main aim of this work is to present a broad overview of the current knowledge on the energy-producing metabolic pathways operating inside sperm mitochondria during capacitation in different mammalian species.
Metabolism of glucose and of other energetic substrates, such as pyruvate, lactate, and citrate, is critically analyzed.
Such knowledge, besides its obvious importance for basic science, could eventually translate into the development of novel strategies for treatment of male infertility, artificial reproduction, and sperm selection methods.
American Psychological Association (APA)
Ferramosca, Alessandra& Zara, Vincenzo. 2014. Bioenergetics of Mammalian Sperm Capacitation. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506698
Modern Language Association (MLA)
Ferramosca, Alessandra& Zara, Vincenzo. Bioenergetics of Mammalian Sperm Capacitation. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-506698
American Medical Association (AMA)
Ferramosca, Alessandra& Zara, Vincenzo. Bioenergetics of Mammalian Sperm Capacitation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506698