Methotrexate Toxicity in Growing Long Bones of Young Rats : A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children
Joint Authors
King, Tristan J.
Georgiou, Kristen R.
Fan, Chiaming
Xian, Cory J.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The advancement and intensive use of chemotherapy in treating childhood cancers has led to a growing population of young cancer survivors who face increased bone health risks.
However, the underlying mechanisms for chemotherapy-induced skeletal defects remain largely unclear.
Methotrexate (MTX), the most commonly used antimetabolite in paediatric cancer treatment, is known to cause bone growth defects in children undergoing chemotherapy.
Animal studies not only have confirmed the clinical observations but also have increased our understanding of the mechanisms underlying chemotherapy-induced skeletal damage.
These models revealed that high-dose MTX can cause growth plate dysfunction, damage osteoprogenitor cells, suppress bone formation, and increase bone resorption and marrow adipogenesis, resulting in overall bone loss.
While recent rat studies have shown that antidote folinic acid can reduce MTX damage in the growth plate and bone, future studies should investigate potential adjuvant treatments to reduce chemotherapy-induced skeletal toxicities.
American Psychological Association (APA)
Fan, Chiaming& Georgiou, Kristen R.& King, Tristan J.& Xian, Cory J.. 2011. Methotrexate Toxicity in Growing Long Bones of Young Rats : A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-506706
Modern Language Association (MLA)
Fan, Chiaming…[et al.]. Methotrexate Toxicity in Growing Long Bones of Young Rats : A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-506706
American Medical Association (AMA)
Fan, Chiaming& Georgiou, Kristen R.& King, Tristan J.& Xian, Cory J.. Methotrexate Toxicity in Growing Long Bones of Young Rats : A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-506706
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506706