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Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nephrotic syndrome (NS) is characterized by heavy proteinuria, hypoalbuminemia, and edema.
The underlying causes of NS are diverse and are tied to inheritable and environmental factors.
A common diagnostic marker for NS is effacement of podocyte foot processes.
The formation and maintenance of foot processes are under the control of many signalling molecules including Rho-GTPases.
Our knowledge of Rho-GTPases is based largely on the functions of three prototypic members: RhoA, Rac1, and Cdc42.
In the event of podocyte injury, the rearrangement to the actin cytoskeleton is orchestrated largely by this family of proteins.
The importance of maintaining proper actin dynamics in podocytes has led to much investigation as to how Rho-GTPases and their regulatory molecules form and maintain foot processes as a critical component of the kidney’s filtration barrier.
Modern sequencing techniques have allowed for the identification of novel disease causing mutations in genes such as ARHGDIA, encoding Rho-GDIα.
Continued use of whole exome sequencing has the potential to lead to the identification of new mutations in genes encoding Rho-GTPases or their regulatory proteins.
Expanding our knowledge of the dynamic regulation of the actin network by Rho-GTPases in podocytes will pave the way for effective therapeutic options for NS patients.
American Psychological Association (APA)
Robins, Richard& Takano, Tomoko. 2014. Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome. Advances in Nephrology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-506710
Modern Language Association (MLA)
Robins, Richard& Takano, Tomoko. Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome. Advances in Nephrology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-506710
American Medical Association (AMA)
Robins, Richard& Takano, Tomoko. Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome. Advances in Nephrology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-506710
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506710