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The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone
Joint Authors
Singh, Shalini
Handa, Divya
Mak, Isabella W. Y.
Ghert, Michelle
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Giant cell tumor of bone (GCT) is a bone tumor consisting of numerous multinucleated osteoclastic giant cells involved in bone resorption and neoplastic osteoblast-like stromal cells responsible for tumor growth.
The tumor occasionally metastasizes to the lung; however, factors leading to metastasis in this tumor are unknown.
The TWIST-1 protein (also referred to as TWIST) has been suggested to be involved in epithelial-mesenchymal transition (EMT) and tumor progression in some cancers.
In this study we investigated the functional role of TWIST in GCT cell angiogenesis and migration.
Overexpression of TWIST in neoplastic GCT stromal cells significantly increased mRNA and protein expression of VEGF and VEGFR1 in vitro, whereas knockdown of TWIST resulted in decreased VEGF and VEGFR1 expression.
A stable cell line with TWIST overexpression resulted in features of EMT including increased cell migration and downregulation of E-cadherin.
The results of our study indicate that TWIST may play an important role in angiogenesis and cell migration in GCT.
American Psychological Association (APA)
Singh, Shalini& Mak, Isabella W. Y.& Handa, Divya& Ghert, Michelle. 2014. The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone. Advances in Biology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506720
Modern Language Association (MLA)
Singh, Shalini…[et al.]. The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone. Advances in Biology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-506720
American Medical Association (AMA)
Singh, Shalini& Mak, Isabella W. Y.& Handa, Divya& Ghert, Michelle. The Role of TWIST in Angiogenesis and Cell Migration in Giant Cell Tumor of Bone. Advances in Biology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506720