The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats
Joint Authors
Luo, Guang-Wei
Gao, Yang
Chung, Peter C. K.
Deng, Xin-Guo
Li, Na
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To compare Ganoderma spores lipid (GSL) and fish oil (FO) in inhibiting retinal photoreceptor cell lesions induced by N-methyl-N-nitrosourea (MNU) in rats.
Methods.
120 rats were untreated (normal control, NC group) or treated with a single intraperitoneal injection of 40 mg/kg MNU (MNU group) then treated with GSL (GSL group) or FO (FO group).
Eyes were obtained at 1, 3, 5, 7, and 10 days.
Results.
Light microscopy assay demonstrated that GSL and FO alleviated rat retinal photoreceptor cell damage (GSL and FO versus MNU group P<.001) similarly (GSL versus FO group P=.980).
Electron microscopy confirmed that GSL and FO reversed damage to photoreceptor segments and photoreceptor cell nuclei.
GSL-treated rats showed significantly elevated a-wave and b-wave amplitudes over MNU group (P<.05) but less than NC group (P<.05) and not significantly different from FO group (P>.05).
Conclusion.
GSL, like FO, alleviates rat retinal photoreceptor cell damage induced by MNU.
American Psychological Association (APA)
Gao, Yang& Deng, Xin-Guo& Li, Na& Luo, Guang-Wei& Chung, Peter C. K.. 2011. The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506721
Modern Language Association (MLA)
Gao, Yang…[et al.]. The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506721
American Medical Association (AMA)
Gao, Yang& Deng, Xin-Guo& Li, Na& Luo, Guang-Wei& Chung, Peter C. K.. The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N-Methyl-N-Nitrosourea-Induced Photoreceptor Cell Lesion in Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506721
