Scorpion Venom and the Inflammatory Response

Author

Petricevich, Vera L.

Source

Mediators of Inflammation

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-03-14

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Diseases

Abstract EN

Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics.

These venoms are associated with high morbility and mortality, especially among children.

Victims of envenoming by a scorpion suffer a variety of pathologies, involving mainly both sympathetic and parasympathetic stimulation as well as central manifestations such as irritability, hyperthermia, vomiting, profuse salivation, tremor, and convulsion.

The clinical signs and symptoms observed in humans and experimental animals are related with an excessive systemic host inflammatory response to stings and stings, respectively.

Although the pathophysiology of envenomation is complex and not yet fully understood, venom and immune responses are known to trigger the release of inflammatory mediators that are largely mediated by cytokines.

In models of severe systemic inflammation produced by injection of high doses of venom or venoms products, the increase in production of proinflammatory cytokines significantly contributes to immunological imbalance, multiple organ dysfunction and death.

The cytokines initiate a cascade of events that lead to illness behaviors such as fever, anorexia, and also physiological events in the host such as activation of vasodilatation, hypotension, and increased of vessel permeability.

American Psychological Association (APA)

Petricevich, Vera L.. 2010. Scorpion Venom and the Inflammatory Response. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-506725

Modern Language Association (MLA)

Petricevich, Vera L.. Scorpion Venom and the Inflammatory Response. Mediators of Inflammation No. 2010 (2010), pp.1-16.
https://search.emarefa.net/detail/BIM-506725

American Medical Association (AMA)

Petricevich, Vera L.. Scorpion Venom and the Inflammatory Response. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-16.
https://search.emarefa.net/detail/BIM-506725

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-506725