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The Antiacetylcholinesterase and Antileishmanial Activities of Canarium patentinervium Miq.
Joint Authors
Khoo, Teng-Jin
Debnath, S.
Adhikari, A.
Wiart, C.
Mogana, R.
Hazra, S.
Hazra, B.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In continuation of our natural and medicinal research programme on tropical rainforest plants, a bioassay guided fractionation of ethanolic extract of leaves of Canarium patentinervium Miq.
(Burseraceae Kunth.) led to the isolation of scopoletin (1), scoparone (2), (+)-catechin (3), vomifoliol (4), lioxin (5), and syringic acid (6).
All the compounds exhibited antiacetylcholinesterase activity with syringic acid, a phenolic acid exhibiting good AChE inhibition (IC50 29.53 ± 0.19 μg/mL).
All compounds displayed moderate antileishmanial activity with scopoletin having the highest antileishmanial activity (IC50 163.30 ± 0.32 μg/mL).
Given the aforementioned evidence, it is tempting to speculate that Canarium patentinervium Miq.
represents an exciting scaffold from which to develop leads for treatment of neurodegenerative and parasitic diseases.
American Psychological Association (APA)
Mogana, R.& Adhikari, A.& Debnath, S.& Hazra, S.& Hazra, B.& Khoo, Teng-Jin…[et al.]. 2014. The Antiacetylcholinesterase and Antileishmanial Activities of Canarium patentinervium Miq.. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506735
Modern Language Association (MLA)
Mogana, R.…[et al.]. The Antiacetylcholinesterase and Antileishmanial Activities of Canarium patentinervium Miq.. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-506735
American Medical Association (AMA)
Mogana, R.& Adhikari, A.& Debnath, S.& Hazra, S.& Hazra, B.& Khoo, Teng-Jin…[et al.]. The Antiacetylcholinesterase and Antileishmanial Activities of Canarium patentinervium Miq.. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506735