Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor
Joint Authors
Yang, Zhengduo
Zhang, Li
Liu, Jun
Lv, Hongcheng
Ding, Po
Li, Yan
Zhang, Dan
Liu, Guang
Zhang, Shiwu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the associations among the number of polyploid giant cancer cells (PGCCs) and vasculogenic mimicry (VM), EZH2 expression, and serous ovarian tumor grade, a total of 80 paraffin-embedded serous ovarian tumor samples including 21 cases of primary carcinoma and their metastatic tumors, 26 cases of primary carcinoma without metastasis, and 12 cases of serous borderline cystadenoma were analyzed.
PGCCs and VM were detected in human serous ovarian tumor.
The metastatic foci of ovarian carcinoma had the highest number of PGCCs and VM.
The number of PGCCs and VM increased with the grade of ovarian carcinomas.
PGCCs generated erythrocytes via budding and together they formed VM.
Tumor cells and cancer-associated fibroblasts were positive for EZH2 immunohistochemical staining.
The tumor cells and cancer associated fibroblasts in the metastatic foci had the highest staining index of EZH2 staining.
Both tumor cells and cancer-associated fibroblasts express EZH2 which then contributes to the malignant grade of serous ovarian tumor.
American Psychological Association (APA)
Zhang, Li& Ding, Po& Lv, Hongcheng& Zhang, Dan& Liu, Guang& Yang, Zhengduo…[et al.]. 2014. Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506737
Modern Language Association (MLA)
Zhang, Li…[et al.]. Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-506737
American Medical Association (AMA)
Zhang, Li& Ding, Po& Lv, Hongcheng& Zhang, Dan& Liu, Guang& Yang, Zhengduo…[et al.]. Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-506737
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506737
