![](/images/graphics-bg.png)
Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling
Joint Authors
Serio, Mario
Luconi, Michaela
Marchiani, Sara
Lombardi, Adriana
Poli, Giada
Cantini, Giulia
Mannelli, Massimo
Piscitelli, Elisabetta
Ercolino, Tonino
Ceni, Elisabetta
Galli, Andrea
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-07-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Rosiglitazone (RGZ), a thiazolidinedione ligand of the peroxisome proliferator-activated receptor (PPAR)-γ, has been recently described as possessing antitumoral properties.
We investigated RGZ effect on cell proliferation in two cell line models (SW13 and H295R) of human adrenocortical carcinoma (ACC) and its interaction with the signaling pathways of the activated IGF-I receptor (IGF-IR).
We demonstrate a high expression of IGF-IR in the two cell lines and in ACC.
Cell proliferation is stimulated by IGF-I in a dose- and time-dependent manner and is inhibited by RGZ.
The analysis of the main intracellular signaling pathways downstream of the activated IGF-IR, phosphatidyl inositol 3-kinase (PI3K)-Akt, and extracellular signal-regulated kinase (ERK1/2) cascades reveals that RGZ rapidly interferes with the Akt and ERK1/2 phosphorylation/activation which mediates IGF-I stimulated proliferation.
In conclusion, our results suggest that RGZ exerts an inhibitory effect on human ACC cell proliferation by interfering with the PI3K/Akt and ERK1/2 signaling pathways downstream of the activated IGF-IR.
American Psychological Association (APA)
Cantini, Giulia& Lombardi, Adriana& Piscitelli, Elisabetta& Poli, Giada& Ceni, Elisabetta& Marchiani, Sara…[et al.]. 2008. Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling. PPAR Research،Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-506788
Modern Language Association (MLA)
Cantini, Giulia…[et al.]. Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling. PPAR Research No. 2008 (2008), pp.1-11.
https://search.emarefa.net/detail/BIM-506788
American Medical Association (AMA)
Cantini, Giulia& Lombardi, Adriana& Piscitelli, Elisabetta& Poli, Giada& Ceni, Elisabetta& Marchiani, Sara…[et al.]. Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-11.
https://search.emarefa.net/detail/BIM-506788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506788