Evaluation of the EndoPAT as a Tool to Assess Endothelial Function
Joint Authors
van Dongen, M. G. J.
Kales, A. J.
Bradnock, D.
Moerland, M.
Burggraaf, J.
Schrier, L.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Endothelial dysfunction is a potential target for (pharmaceutical) intervention of several systemic pathological conditions.
We investigated the feasibility of the EndoPAT to evaluate acute changes in endothelial function with repeated noninvasive measurements and assessed its discriminating power in different populations.
Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%).
Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4 and 1.8±0.3, resp., versus 1.8±0.5, P>0.05).
The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline 0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline 0.49±0.92, 95% confidence interval −0.47 to 1.46).
This suggests that at present the EndoPAT might not be suitable to assess (changes in) endothelial function in early-phase clinical pharmacology studies.
Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques.
This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.
American Psychological Association (APA)
Moerland, M.& Kales, A. J.& Schrier, L.& van Dongen, M. G. J.& Bradnock, D.& Burggraaf, J.. 2012. Evaluation of the EndoPAT as a Tool to Assess Endothelial Function. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-506798
Modern Language Association (MLA)
Moerland, M.…[et al.]. Evaluation of the EndoPAT as a Tool to Assess Endothelial Function. International Journal of Vascular Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-506798
American Medical Association (AMA)
Moerland, M.& Kales, A. J.& Schrier, L.& van Dongen, M. G. J.& Bradnock, D.& Burggraaf, J.. Evaluation of the EndoPAT as a Tool to Assess Endothelial Function. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-506798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506798