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Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma
Joint Authors
Grazi, Gian Luca
Vivarelli, Marco
Vetrone, Gaetano
Del Gaudio, Massimo
Bertuzzo, Valentina
Pinna, Antonio Daniele
Cescon, Matteo
Ravaioli, Matteo
Di Gioia, Paolo
Ercolani, Giorgio
D'Errico-Grigioni, Antonietta
Dazzi, Alessandro
Cucchetti, Alessandro
Lauro, Augusto
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Factors affecting outcomes after orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) have been extensively studied, but some of them have only recently been discovered or reassessed.
Methods.
We analyzed classical and more recently emerging variables with a hypothetical impact on recurrence-free survival (RFS) in a single-center series of 283 patients transplanted for HCC between 1997 and 2009.
Results.
Five-year patient survival and RFS were 75% and 86%, respectively.
Thirty-four (12%) patients had HCC recurrence.
Elevated preoperative alpha-fetoprotein (AFP) levels, preoperative treatments of HCC, unfulfilled Milan and up-to-seven criteria at final histology, poor tumor differentiation, and tumor microvascular invasion negatively affected RFS by univariate analysis.
Milan and up-to-seven criteria applied preoperatively, and the use of m-TOR inhibitors did not reach statistical significance.
Cox's proportional hazard model showed that only elevated AFP levels (Odds Ratio=2.88; 95% C.I.=1.43–5.80; P=.003), preoperative tumor treatments (Odds Ratio=4.84; 95% C.I.=1.42–16.42; P=.01), and microvascular invasion (Odds Ratio=4.82; 95% C.I.=1.87–12.41; P=.001) were predictors of lower RFS.
Conclusions.
Biological aggressiveness and preoperative tumor treatment, rather than traditional and expanded dimensional criteria, conditioned the outcomes in patients transplanted for HCC.
American Psychological Association (APA)
Cescon, Matteo& Ravaioli, Matteo& Grazi, Gian Luca& Ercolani, Giorgio& Cucchetti, Alessandro& Bertuzzo, Valentina…[et al.]. 2010. Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma. Journal of Transplantation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-506799
Modern Language Association (MLA)
Cescon, Matteo…[et al.]. Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma. Journal of Transplantation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-506799
American Medical Association (AMA)
Cescon, Matteo& Ravaioli, Matteo& Grazi, Gian Luca& Ercolani, Giorgio& Cucchetti, Alessandro& Bertuzzo, Valentina…[et al.]. Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma. Journal of Transplantation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-506799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506799