![](/images/graphics-bg.png)
The Role of PPARs in the Endothelium : Implications for Cancer Therapy
Joint Authors
Swales, Karen E.
Bishop-Bailey, David
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The growth and metastasis of cancers intimately involve the vasculature and in particular the endothelial cell layer.
Tumours require new blood vessel formation via angiogenesis to support growth.
In addition, inflammation, coagulation, and platelet activation are common signals in the growth and metastasis of tumour cells.
The endothelium plays a central role in the homeostatic control of inflammatory cell recruitment, regulating platelet activation and coagulation pathways.
PPARα, -β/δ, and -γ are all expressed in endothelial cells.
This review will discuss the roles of PPARs in endothelial cells in relation to angiogenesis, inflammation, coagulation, and platelet control pathways.
In particular, we will discuss the recent evidence that supports the hypothesis that PPARα and PPARγ are antiangiogenic receptors, while PPARβ/δ is proangiogenic.
American Psychological Association (APA)
Bishop-Bailey, David& Swales, Karen E.. 2008. The Role of PPARs in the Endothelium : Implications for Cancer Therapy. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-506809
Modern Language Association (MLA)
Bishop-Bailey, David& Swales, Karen E.. The Role of PPARs in the Endothelium : Implications for Cancer Therapy. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-506809
American Medical Association (AMA)
Bishop-Bailey, David& Swales, Karen E.. The Role of PPARs in the Endothelium : Implications for Cancer Therapy. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-506809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506809