Ulinastatin Suppresses Burn-Induced Lipid Peroxidation and Reduces Fluid Requirements in a Swine Model
Joint Authors
Zhang, Lin
Lv, Yi
Hu, Quan
Luo, Hong-Min
Du, Ming-Hua
Pi, Yu-Li
Wang, Huan
Wen, Yu
Lin, Zhi-Long
Lin, Hong-Yuan
Ma, Li
Hu, Sen
Sheng, Zhi-Yong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Objective.
Lipid peroxidation plays a critical role in burn-induced plasma leakage, and ulinastatin has been reported to reduce lipid peroxidation in various models.
This study aims to examine whether ulinastatin reduces fluid requirements through inhibition of lipid peroxidation in a swine burn model.
Methods.
Forty miniature swine were subjected to 40% TBSA burns and were randomly allocated to the following four groups: immediate lactated Ringer's resuscitation (ILR), immediate LR containing ulinastatin (ILR/ULI), delayed LR resuscitation (DLR), and delayed LR containing ulinastatin (DLR/ULI).
Hemodynamic variables, net fluid accumulation, and plasma thiobarbituric acid reactive substances (TBARS) concentrations were measured.
Heart, liver, lung, skeletal muscle, and ileum were harvested at 48 hours after burn for evaluation of TBARS concentrations, activities of antioxidant enzymes, and tissue water content.
Results.
Ulinastatin significantly reduced pulmonary vascular permeability index (PVPI) and extravascular lung water index (ELWI), net fluid accumulation, and water content of heart, lung, and ileum in both immediate or delayed resuscitation groups.
Furthermore, ulinastatin infusion significantly reduced plasma and tissue concentrations of TBARS in both immediate or delayed resuscitation groups.
Conclusions.
These results indicate that ulinastatin can reduce fluid requirements through inhibition of lipid peroxidation.
American Psychological Association (APA)
Luo, Hong-Min& Du, Ming-Hua& Lin, Zhi-Long& Hu, Quan& Zhang, Lin& Ma, Li…[et al.]. 2013. Ulinastatin Suppresses Burn-Induced Lipid Peroxidation and Reduces Fluid Requirements in a Swine Model. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506823
Modern Language Association (MLA)
Luo, Hong-Min…[et al.]. Ulinastatin Suppresses Burn-Induced Lipid Peroxidation and Reduces Fluid Requirements in a Swine Model. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506823
American Medical Association (AMA)
Luo, Hong-Min& Du, Ming-Hua& Lin, Zhi-Long& Hu, Quan& Zhang, Lin& Ma, Li…[et al.]. Ulinastatin Suppresses Burn-Induced Lipid Peroxidation and Reduces Fluid Requirements in a Swine Model. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506823