Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line
Joint Authors
Shih, I-Chen
Hu, Jhe-Cyuan
Chiang, Hsiu-Mei
Chang, Hsien-Chang
Liao, Sue-Tsai
Wen, Kuo-Ching
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study investigated whether Terminalia catappa L.
hydrophilic extract (TCLW) prevents photoaging in human dermal fibroblasts after exposure to UVB radiation.
TCLW exhibited DPPH free radical scavenging activity and protected erythrocytes against AAPH-induced hemolysis.
In the gelatin digestion assay, the rates of collagenase inhibition by TCL methanol extract, TCLW, and its hydrolysates were greater than 100% at the concentration of 1 mg/mL.
We found that serial dilutions of TCLW (10–500 μg/mL) inhibited collagenase activity in a dose-dependent manner (82.3% to 101.0%).
However, TCLW did not significantly inhibit elastase activity.
In addition, TCLW inhibited MMP-1 and MMP-9 protein expression at a concentration of 25 μg/mL and inhibited MMP-3 protein expression at a concentration of 50 μg/mL.
TCLW also promoted the protein expression of type I procollagen.
We also found that TCLW attenuated the expression of MMP-1, -3, and -9 by inhibiting the phosphorylation of ERK, JNK, and p38.
These findings suggest that TCLW increases the production of type I procollagen by inhibiting the activity of MMP-1, -3 and -9, and, therefore, has potential use in anti-aging cosmetics.
American Psychological Association (APA)
Wen, Kuo-Ching& Shih, I-Chen& Hu, Jhe-Cyuan& Liao, Sue-Tsai& Chang, Hsien-Chang& Chiang, Hsiu-Mei. 2010. Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-506830
Modern Language Association (MLA)
Wen, Kuo-Ching…[et al.]. Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-506830
American Medical Association (AMA)
Wen, Kuo-Ching& Shih, I-Chen& Hu, Jhe-Cyuan& Liao, Sue-Tsai& Chang, Hsien-Chang& Chiang, Hsiu-Mei. Inhibitory Effects of Terminalia catappa on UVB-Induced Photodamage in Fibroblast Cell Line. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-506830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506830