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Viral Vector Induction of CREB Expression in the Periaqueductal Gray Induces a Predator Stress-Like Pattern of Changes in pCREB Expression, Neuroplasticity, and Anxiety in Rodents
Joint Authors
Berton, Olivier
Adamec, Robert
Abdul Razek, Waleed
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-01
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Predator stress is lastingly anxiogenic.
Phosphorylation of CREB to pCREB (phosphorylated cyclic AMP response element binding protein) is increased after predator stress in fear circuitry, including in the right lateral column of the PAG (periaqueductal gray).
Predator stress also potentiates right but not left CeA-PAG (central amygdala-PAG) transmission up to 12 days after stress.
The present study explored the functional significance of pCREB changes by increasing CREB expression in non-predator stressed rats through viral vectoring, and assessing the behavioral, electrophysiological and pCREB expression changes in comparison with handled and predator stressed controls.
Increasing CREB expression in right PAG was anxiogenic in the elevated plus maze, had no effect on risk assessment, and increased acoustic startle response while delaying startle habituation.
Potentiation of the right but not left CeA-PAG pathway was also observed.
pCREB expression was slightly elevated in the right lateral column of the PAG, while the dorsal and ventral columns were not affected.
The findings of this study suggest that by increasing CREB and pCREB in the right lateral PAG, it is possible to produce rats that exhibit behavioral, brain, and molecular changes that closely resemble those seen in predator stressed rats.
American Psychological Association (APA)
Adamec, Robert& Berton, Olivier& Abdul Razek, Waleed. 2009. Viral Vector Induction of CREB Expression in the Periaqueductal Gray Induces a Predator Stress-Like Pattern of Changes in pCREB Expression, Neuroplasticity, and Anxiety in Rodents. Neural Plasticity،Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-506834
Modern Language Association (MLA)
Adamec, Robert…[et al.]. Viral Vector Induction of CREB Expression in the Periaqueductal Gray Induces a Predator Stress-Like Pattern of Changes in pCREB Expression, Neuroplasticity, and Anxiety in Rodents. Neural Plasticity No. 2009 (2009), pp.1-15.
https://search.emarefa.net/detail/BIM-506834
American Medical Association (AMA)
Adamec, Robert& Berton, Olivier& Abdul Razek, Waleed. Viral Vector Induction of CREB Expression in the Periaqueductal Gray Induces a Predator Stress-Like Pattern of Changes in pCREB Expression, Neuroplasticity, and Anxiety in Rodents. Neural Plasticity. 2009. Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-506834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506834