Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery
Joint Authors
Li, Huanan
Liu, Jun
Cui, Yani
Huang, Yihang
Sun, Yong
Zhang, Xingdong
Fan, Yujiang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Reduction-triggered breakable polymeric micelles incorporated with MTX were prepared using amphiphilic PAA-g-PEG copolymers having S–S bonds in the backbone.
The micelles were spherical with diameters less than 70 nm.
The micelles could encapsulate the hydrophobic MTX in the hydrophobic core.
The drug loading content and drug loading efficiency of the micelles were highly dependent on the copolymer chemical structure, ranging from 2.9 to 7.5% and 31.9 to 82.5%, respectively.
Both the drug loading content and drug loading efficiency increased along with more hydrophobic segments in the copolymers.
In normal circumstance, these micelles were capable of keeping stable and hold most of the MTX in the core, stabilizing the incorporated MTX through the π-π stacking with the phenyl groups in the backbone of the copolymers.
In reductive environments that mimicked the intracellular compartments, the entire MTX payload could be quickly released due to the reduction-triggered breakage of the micelles.
These micelles showed good antiproliferative activity against several cancer cell lines, including KB, 4T-1 and HepG2, especially within the low drug concentration scope.
American Psychological Association (APA)
Huang, Yihang& Liu, Jun& Cui, Yani& Li, Huanan& Sun, Yong& Fan, Yujiang…[et al.]. 2014. Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-506846
Modern Language Association (MLA)
Huang, Yihang…[et al.]. Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-506846
American Medical Association (AMA)
Huang, Yihang& Liu, Jun& Cui, Yani& Li, Huanan& Sun, Yong& Fan, Yujiang…[et al.]. Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-506846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506846