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Statins : Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins
Joint Authors
Morales-Villegas, Enrique C.
Di Sciascio, Germano
Briguori, Carlo
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Reduction of LDL-cholesterol concentration in serum, blocking the isoprenylation of GTPases and the activation of myocyte-protective enzyme systems are three mechanisms that currently explain the lipid and non-lipid effects of statins.
However, the decrease of LDL-cholesterol, the reduction of inflammation biomarkers and even the atheroregresion, as surrogate effects to the mechanisms of action of statins would be irrelevant if not accompanied by a significant decrease in the incidence of cardiovascular events.
Statins like no other pharmacological group have proven to reduce the incidence of cardiovascular events and prolong life in any clinical scenario.
This article review the basic and clinical evidence that support a new indication for HMG-CoA reductase inhibitors “pharmacological myocardial preconditioning before anticipated ischemia” or hyperacute use of statins in subjects with any coronary syndrome eligible for elective, semi-urgent or primary percutaneous coronary intervention: ARMYDA-Original, NAPLES I-II, ARMYDA-ACS, ARMYDA-RECAPTURE, Non-STEMI-Korean, Korean-STEMI trials.
American Psychological Association (APA)
Morales-Villegas, Enrique C.& Di Sciascio, Germano& Briguori, Carlo. 2011. Statins : Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-506858
Modern Language Association (MLA)
Morales-Villegas, Enrique C.…[et al.]. Statins : Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins. International Journal of Hypertension No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-506858
American Medical Association (AMA)
Morales-Villegas, Enrique C.& Di Sciascio, Germano& Briguori, Carlo. Statins : Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-506858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506858