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Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons
Joint Authors
Branchereau, Pascal
Allain, Anne-Emilie
Le Corronc, Hervé
Meyrand, Pierre
Cazenave, William
Legendre, Pascal
Delpy, Alain
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
γ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates.
In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor.
In the present paper, we concentrate on brainstem and spinal motoneurons that are largely targeted by GABAergic interneurons, and we bring together data on the switch from excitatory to inhibitory effects of GABA, on the maturation of the GABAergic system and GABAAR subunits.
We finally discuss the role of GABA and its GABAAR in immature hypoglossal motoneurons of the spastic (SPA) mouse, a model of human hyperekplexic syndrome.
American Psychological Association (APA)
Allain, Anne-Emilie& Le Corronc, Hervé& Delpy, Alain& Cazenave, William& Meyrand, Pierre& Legendre, Pascal…[et al.]. 2011. Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons. Neural Plasticity،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-506930
Modern Language Association (MLA)
Allain, Anne-Emilie…[et al.]. Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons. Neural Plasticity No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-506930
American Medical Association (AMA)
Allain, Anne-Emilie& Le Corronc, Hervé& Delpy, Alain& Cazenave, William& Meyrand, Pierre& Legendre, Pascal…[et al.]. Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-506930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506930