The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by D-Galactosamine in Rats
Joint Authors
Zhu, Hong
Zhong, Sen
Yang, Fang
Zhang, Yang
Hu, Xiaoyu
Wang, Yanyan
Yi, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Qinggan Huoxue Recipe is a traditional Chinese medicine, which has been usually used to improve liver function in hepatitis.
In order to investigate the effects of high-dose Qinggan Huoxue Recipe on acute liver failure and explore the potential mechanism, we had built acute liver failure models in rats by intraperitoneal injection of D-galactosamine (D-GalN).
High-dose Qinggan Huoxue Recipe was delivered by gavage.
After treatment, the blood alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), albumin (ALB), cholinesterase (CHE), and prothrombin time (PT) were determined.
The pathological score of liver tissue was recorded.
Proliferating cell nuclear antigen (PCNA) immunohistochemistry staining and fluorescence quantitative reverse transcription polymerase chain reaction (qRT-PCR) of high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), nuclear factor-kappa B (NF-κB), and Caspase-3 were performed.
The survival curve was also depicted.
Our results demonstrated that high-dose Qinggan Huoxue Recipe could significantly improve liver function and increase survival rates in rats with acute liver failure.
These effects were supposed to be mediated by suppressing inflammatory reaction and apoptosis.
American Psychological Association (APA)
Zhu, Hong& Zhang, Yang& Hu, Xiaoyu& Yi, Cheng& Zhong, Sen& Wang, Yanyan…[et al.]. 2013. The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by D-Galactosamine in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506942
Modern Language Association (MLA)
Zhu, Hong…[et al.]. The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by D-Galactosamine in Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506942
American Medical Association (AMA)
Zhu, Hong& Zhang, Yang& Hu, Xiaoyu& Yi, Cheng& Zhong, Sen& Wang, Yanyan…[et al.]. The Effects of High-Dose Qinggan Huoxue Recipe on Acute Liver Failure Induced by D-Galactosamine in Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506942