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Fish Suppressors of Cytokine Signaling (SOCS) : Gene Discovery, Modulation of Expression and Function
Joint Authors
Vecino, Jose L. González
Secombes, Christopher J.
Holland, Jason W.
Gorgoglione, Bartolomeo
Wadsworth, Simon
Wang, Tiehui
Maehr, Tanja
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-13
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
The intracellular suppressors of cytokine signaling (SOCS) family members, including CISH and SOCS1 to 7 in mammals, are important regulators of cytokine signaling pathways.
So far, the orthologues of all the eight mammalian SOCS members have been identified in fish, with several of them having multiple copies.
Whilst fish CISH, SOCS3, and SOCS5 paralogues are possibly the result of the fish-specific whole genome duplication event, gene duplication or lineage-specific genome duplication may also contribute to some paralogues, as with the three trout SOCS2s and three zebrafish SOCS5s.
Fish SOCS genes are broadly expressed and also show species-specific expression patterns.
They can be upregulated by cytokines, such as IFN-γ, TNF-α, IL-1β, IL-6, and IL-21, by immune stimulants such as LPS, poly I:C, and PMA, as well as by viral, bacterial, and parasitic infections in member- and species-dependent manners.
Initial functional studies demonstrate conserved mechanisms of fish SOCS action via JAK/STAT pathways.
American Psychological Association (APA)
Wang, Tiehui& Gorgoglione, Bartolomeo& Maehr, Tanja& Holland, Jason W.& Vecino, Jose L. González& Wadsworth, Simon…[et al.]. 2011. Fish Suppressors of Cytokine Signaling (SOCS) : Gene Discovery, Modulation of Expression and Function. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-506952
Modern Language Association (MLA)
Wang, Tiehui…[et al.]. Fish Suppressors of Cytokine Signaling (SOCS) : Gene Discovery, Modulation of Expression and Function. Journal of Signal Transduction No. 2011 (2011), pp.1-20.
https://search.emarefa.net/detail/BIM-506952
American Medical Association (AMA)
Wang, Tiehui& Gorgoglione, Bartolomeo& Maehr, Tanja& Holland, Jason W.& Vecino, Jose L. González& Wadsworth, Simon…[et al.]. Fish Suppressors of Cytokine Signaling (SOCS) : Gene Discovery, Modulation of Expression and Function. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-20.
https://search.emarefa.net/detail/BIM-506952
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506952