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The Histological and Immunohistochemical Aspects of Bile Reflux in Patients with Gastroesophageal Reflux Disease
Joint Authors
Giatromanolaki, Alexandra
Kouklakis, Georgios
Pitiakoudis, Michael
Simopoulos, Konstantinos
Liratzopoulos, Nikolaos
Efraimidou, Eleni
Sivridis, Efthimios
Zezos, Petros
Polychronidis, Alexandros
Nakos, Andreas
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
The pathogenesis of GERD is strongly related with mixed acid and bile reflux.
Benign and malignant esophageal and gastric lesions have been associated with synergetic activity between those parameters.
Bile reflux causes reactive gastropathy evaluated with Bile Reflux Index (BRI).
The aim was to investigate if the sequence: bile reflux-intestinal metaplasia-GERD-esophagitis, is associated with apoptotic/oncogenetic disturbances.
Materials/Methods.
Fifteen asymptomatic subjects and 53 GERD patients underwent gastroscopy with biopsies.
The specimens examined histologically and immunohistochemically for p53, Ki-67, Bax, and Bcl-2.
Results.
Elevated BRI score detected in 47% (25/53) of patients with GERD and in 13% (2/15) of controls (P=0.02).
Severe esophageal lesions were significantly more common in BRI (+) patients (14/25) compared to BRI (−) ones (P=0.0049).
Immunohistochemical analysis did not show associations between BRI score and biomarker expression.
Conclusions.
Bile reflux gastropathy is associated with GERD severity, but not with oncogene expression or apoptotic discrepancies of the upper GI mucosa.
American Psychological Association (APA)
Nakos, Andreas& Kouklakis, Georgios& Pitiakoudis, Michael& Zezos, Petros& Efraimidou, Eleni& Giatromanolaki, Alexandra…[et al.]. 2011. The Histological and Immunohistochemical Aspects of Bile Reflux in Patients with Gastroesophageal Reflux Disease. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-506960
Modern Language Association (MLA)
Nakos, Andreas…[et al.]. The Histological and Immunohistochemical Aspects of Bile Reflux in Patients with Gastroesophageal Reflux Disease. Gastroenterology Research and Practice No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-506960
American Medical Association (AMA)
Nakos, Andreas& Kouklakis, Georgios& Pitiakoudis, Michael& Zezos, Petros& Efraimidou, Eleni& Giatromanolaki, Alexandra…[et al.]. The Histological and Immunohistochemical Aspects of Bile Reflux in Patients with Gastroesophageal Reflux Disease. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-506960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506960