Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis
Joint Authors
Bansal, Abanesh kumar
Pande, Vishal
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
In the present investigation, pulsatile release beads were prepared by ionic gelation technique.
Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.
The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.
In vitro release study showed lag time of 5–8 h before release of lornoxicam from the formulated beads.
Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.
American Psychological Association (APA)
Bansal, Abanesh kumar& Pande, Vishal. 2012. Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506988
Modern Language Association (MLA)
Bansal, Abanesh kumar& Pande, Vishal. Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis. Journal of Pharmaceutics No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506988
American Medical Association (AMA)
Bansal, Abanesh kumar& Pande, Vishal. Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506988