Anti-Proliferative Effect and Phytochemical Analysis of Cymbopogon citratus Extract
Joint Authors
Sheikh, Bassem Y.
Halabi, Mohammed F.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The antiproliferative and antioxidant potential of Cymbopogon citratus (Lemon grass) extracts were investigated.
The extracts were isolated by solvent maceration method and thereafter subjected to antiproliferative activity test on five different cancer cells: human colon carcinoma (HCT-116), breast carcinoma (MCF-7 and MDA-MB 231), ovarian carcinoma (SKOV-3 and COAV), and a normal liver cell line (WRL 68).
The cell viability was determined using MTT assay.
The DPPH radical scavenging assay revealed a concentration dependent trend.
A maximum percentage inhibition of 45% and an IC50 of 278 μg/mL were observed when aqueous extract was evaluated.
In contrast, 48.3% and IC50 of 258.9 μg/mL were observed when 50% ethanolic extract was evaluated.
Both extracts at concentration of 50 to 800 μg/mL showed appreciative metal chelating activity with IC50 value of 172.2±31 μg/mL to 456.5±30 μg/mL.
Depending on extraction solvent content, extract obtained from 50% ethanolic solvent proved to be more potent on breast cancer MCF-7 cell line (IC50 = 68 μg/mL).
On the other hand, 90% ethanolic extract showed a moderate potency on the ovarian cancer (COAV) and MCF-7 cells having an IC50 of 104.6 μg/mL each.
These results suggested antiproliferative efficacy of C.
citratus ethanolic extract against human cancer cell lines.
American Psychological Association (APA)
Halabi, Mohammed F.& Sheikh, Bassem Y.. 2014. Anti-Proliferative Effect and Phytochemical Analysis of Cymbopogon citratus Extract. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506994
Modern Language Association (MLA)
Halabi, Mohammed F.& Sheikh, Bassem Y.. Anti-Proliferative Effect and Phytochemical Analysis of Cymbopogon citratus Extract. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-506994
American Medical Association (AMA)
Halabi, Mohammed F.& Sheikh, Bassem Y.. Anti-Proliferative Effect and Phytochemical Analysis of Cymbopogon citratus Extract. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506994