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Animal Models of GWAS-Identified Type 2 Diabetes Genes
Joint Authors
da Silva Xavier, Gabriela
Rutter, Guy A.
Bellomo, Elisa A.
McGinty, James A.
French, Paul M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D).
Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models.
We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.
American Psychological Association (APA)
da Silva Xavier, Gabriela& Bellomo, Elisa A.& McGinty, James A.& French, Paul M.& Rutter, Guy A.. 2013. Animal Models of GWAS-Identified Type 2 Diabetes Genes. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-507032
Modern Language Association (MLA)
da Silva Xavier, Gabriela…[et al.]. Animal Models of GWAS-Identified Type 2 Diabetes Genes. Journal of Diabetes Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-507032
American Medical Association (AMA)
da Silva Xavier, Gabriela& Bellomo, Elisa A.& McGinty, James A.& French, Paul M.& Rutter, Guy A.. Animal Models of GWAS-Identified Type 2 Diabetes Genes. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-507032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507032