Teratogenic Effect of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on Nissl Substances of Albino Wistar Rat Fetuses
Joint Authors
Nwakanma, Agnes O.
Akpantah, Amabe O.
Ekanem, Theresa B.
Udoh, Paul B.
Asuquo, Olaitan R.
Eluwa, Mokutima A.
Ekong, Moses B.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Rauwolfia vomitoria is a plant used for the treatment of insanity.
The possible adverse effects of crude ethanolic root bark and leaf extract of the plant on Nissl substances of albino Wistar rat fetuses were studied using 25 mature female Wistar rats.
The animals were divided equally into 5 groups, labeled A, B, C, D, and E.
Group A was the control, while groups B, C, D, and E were the experimental.
The female rats were mated with the males overnight, and the sperm positive day was designated as day zero of pregnancy.
Oral doses of 150 mg/kg and 250 mg/kg body weight of the root bark extract were administered to groups B and C animals, respectively, while groups D and E animals received 150 mg/kg and 250 mg/kg body weight of the leaf extract, respectively, from day 7 to 11 of gestation.
On day 20 of gestation, the rats were sacrificed, the fetuses brains extracted, and the cerebral cortices excised and routinely processed for Nissl substances using Cresyl fast violet staining method.
Results showed reduced staining intensity of Nissl substances in the treated groups, especially those that received the root extract.
Thus, the herbs may have adverse effects on protein synthesis within the cerebral cortex.
American Psychological Association (APA)
Eluwa, Mokutima A.& Ekanem, Theresa B.& Udoh, Paul B.& Ekong, Moses B.& Asuquo, Olaitan R.& Akpantah, Amabe O.…[et al.]. 2013. Teratogenic Effect of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on Nissl Substances of Albino Wistar Rat Fetuses. Neuroscience Journal،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-507036
Modern Language Association (MLA)
Eluwa, Mokutima A.…[et al.]. Teratogenic Effect of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on Nissl Substances of Albino Wistar Rat Fetuses. Neuroscience Journal No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-507036
American Medical Association (AMA)
Eluwa, Mokutima A.& Ekanem, Theresa B.& Udoh, Paul B.& Ekong, Moses B.& Asuquo, Olaitan R.& Akpantah, Amabe O.…[et al.]. Teratogenic Effect of Crude Ethanolic Root Bark and Leaf Extracts of Rauwolfia vomitoria (Apocynaceae) on Nissl Substances of Albino Wistar Rat Fetuses. Neuroscience Journal. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-507036
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507036