DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions
Joint Authors
Stefanowicz, Piotr
Kucharczyk-Klamińska, Marzena
Staszewska, Anna
Skała, Jacek
Jeżowska-Bojczuk, Małgorzata
Szczepanik, Wojciech
Szewczuk, Zbigniew
Mysiak, Andrzej
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Three model dipeptides containing 3-(2,3-di(pyridin-2-yl)quinoxalin-6-yl)alanine, 3-(dipyrido[3,2-a:2,3-c]phenazin-11-yl)alanine, and 3-(2,3-diphenylquinoxalin-6-yl)alanine were studied with respect to their ability to bind selected transition metal ions, such as Cu(II), Fe(II), Ni(II), Co(II), Mn(II), and Cr(III).
It was found that only Cu(II) and Fe(II) ions could form stable complex species with the studied compounds.
The ability to form the complexes correlated well with DNA damage experiments.
Only the ferrous and cupric complexes are capable of generating both single- and double-strand scissions.
However, double-strand breakages appear to be dominating lesions in the presence of hydrogen peroxide, especially for copper(II) containing systems.
The quantity of breakage products in the presence of N-(3-(dipyrido[3,2-a:2,3-c]phenazine-11-yl)alanyl)glycine complexes was the highest as compared to the complexes of the remaining compounds.
Moreover, this ligand was the only one that cleaved DNA in the absence of either Cu(II) or Fe(II) ions.
American Psychological Association (APA)
Szczepanik, Wojciech& Kucharczyk-Klamińska, Marzena& Stefanowicz, Piotr& Staszewska, Anna& Szewczuk, Zbigniew& Skała, Jacek…[et al.]. 2010. DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-507053
Modern Language Association (MLA)
Szczepanik, Wojciech…[et al.]. DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-507053
American Medical Association (AMA)
Szczepanik, Wojciech& Kucharczyk-Klamińska, Marzena& Stefanowicz, Piotr& Staszewska, Anna& Szewczuk, Zbigniew& Skała, Jacek…[et al.]. DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions. Bioinorganic Chemistry and Applications. 2010. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-507053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507053