Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Novel amphiphilic biopolymers were synthesized using hyaluronic acid (HA) as a hydrophilic segment and deoxycholic acid (DOCA) as a hydrophobic segment by a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide mediated coupling reaction.
The structural characteristics of the HA-DOCA conjugates were investigated using H1 NMR.
Self-assembled nanoparticles were prepared based on HA-DOCA conjugates, and its characteristics were investigated using dynamic laser light scattering, transmission electron microscopy (TEM), and fluorescence spectroscopy.
The mean diameter was about 293.5 nm with unimodal size distribution in distilled water.
The TEM images revealed that the shape of HA-DOCA self-aggregates was spherical.
The critical aggregation concentration (CAC) was in the range of 0.025–0.056 mg/mL.
The partition equilibrium constant (Kv) of pyrene in self-aggregates solution was from 1.45×104 to 3.64×104.
The aggregation number of DOCA groups per hydrophobic microdomain, estimated by the fluorescence quenching method using cetylpyridinium chloride, increased with increasing degree of substitution.
American Psychological Association (APA)
Dong, Xuemeng& Liu, Chenguang. 2010. Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates. Journal of Nanomaterials،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-507067
Modern Language Association (MLA)
Dong, Xuemeng& Liu, Chenguang. Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates. Journal of Nanomaterials No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-507067
American Medical Association (AMA)
Dong, Xuemeng& Liu, Chenguang. Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates. Journal of Nanomaterials. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-507067
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507067