Patched Knockout Mouse Models of Basal Cell Carcinoma
Joint Authors
Frommhold, Anke
Schulz-Schaeffer, Walter
Nitzki, Frauke
Becker, Marco
Hahn, Heidi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Basal cell carcinoma (BCC) is the most common human tumor.
Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC.
Due to their high and increasing incidence, BCC are becoming all the more important for the health care system.
Adequate animal models are required for the improvement of current treatment strategies.
A good model should reflect the situation in humans (i.e., BCC initiation due to Ptch mutations on an immunocompetent background) and should allow for (i) BCC induction at a defined time point, (ii) analysis of defined BCC stages, and (iii) induction of BCC in 100% of animals.
In addition, it should be easy to handle.
Here, we compare several currently existing conventional and conditional Ptch knockout mouse models for BCC and their potential use in preclinical research.
In addition, we provide new data using conditional Ptchflox/flox mice and the K5-Cre-ERT+/− driver.
American Psychological Association (APA)
Nitzki, Frauke& Becker, Marco& Frommhold, Anke& Schulz-Schaeffer, Walter& Hahn, Heidi. 2012. Patched Knockout Mouse Models of Basal Cell Carcinoma. Journal of Skin Cancer،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-507146
Modern Language Association (MLA)
Nitzki, Frauke…[et al.]. Patched Knockout Mouse Models of Basal Cell Carcinoma. Journal of Skin Cancer No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-507146
American Medical Association (AMA)
Nitzki, Frauke& Becker, Marco& Frommhold, Anke& Schulz-Schaeffer, Walter& Hahn, Heidi. Patched Knockout Mouse Models of Basal Cell Carcinoma. Journal of Skin Cancer. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-507146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507146