Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS
Joint Authors
Bataveljic, Danijela
Milosevic, Milena
Andjus, Pavle
Radenovic, Lidija
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Recently neuroinflammation has gained a particular focus as a key mechanism of ALS.
Several studies in vivo as well as in vitro have nominated immunoglobulin G (IgG) isolated from ALS patients as an active contributor to disease onset and progression.
We have shown that ALS IgG affects astroglial Ca2+ excitability and induces downstream activation of phosphatidylinositol 3-kinase.
These studies were hampered by a lack of knowledge of the pathway of entry of immune factors in the CNS.
Our MRI data revealed the blood-brain barrier BBB leakage and T cell infiltration into brain parenchyma in ALS G93A rats.
Since astrocyte ensheathes blood vessel wall contributing to BBB stability and plays an important role in ALS pathogenesis, we have studied astrocytic membrane proteins water channel aquaporin-4 and the inwardly rectifying potassium channel.
In this review, we will summarize data related to BBB disruption with particular emphasis on impaired function of astrocytes in ALS.
We will discuss implication of membrane proteins expressed on astrocytic endfeet, aquaporin-4, and inwardly rectifying potassium channel in the pathology of ALS.
In addition to ALS-specific IgGs, these membrane proteins are proposed as novel biomarkers of the disease.
American Psychological Association (APA)
Bataveljic, Danijela& Milosevic, Milena& Radenovic, Lidija& Andjus, Pavle. 2014. Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-507147
Modern Language Association (MLA)
Bataveljic, Danijela…[et al.]. Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-507147
American Medical Association (AMA)
Bataveljic, Danijela& Milosevic, Milena& Radenovic, Lidija& Andjus, Pavle. Novel Molecular Biomarkers at the Blood-Brain Barrier in ALS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-507147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507147