Estimation of Insulin Resistance in Mexican Adults by the [13C]Glucose Breath Test Corrected for Endogenous Total CO2 Production
Joint Authors
Valencia, Mauro E.
Candia Plata, Maria del Carmen
Ibarra-Pastrana, Erika
Alvarez, Gerardo
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To evaluate the efficacy of the [13C]glucose breath test for measuring insulin resistance in Mexican adults with different glycemic states.
Research Design and Methods.
Fifty-eight adults underwent a [13C]glucose breath test with simultaneous measurement of total CO2 production by indirect calorimetry, at baseline and 90 minutes after the ingestion of 15 g of dextrose and 25 mg of [13C]glucose.
HOMA was used as a marker of insulin resistance.
Results.
We found an inverse correlation between HOMA and the breath test δ13CO2 (‰), r=-0.41 (P=0.001).
After adjusting for total CO2 production, correlations between HOMA and fasting glucose were less strong but remained significant.
An ROC curve was constructed using δ13CO2 (‰) and HOMA values; the cut-off point was 9.99‰ δ13CO2, corresponding to a sensitivity of 80.0 (95% CI: 51.9, 95.7) and a specificity of 67.4 (95% CI: 51.5, 80.9).
Conclusions.
The [13C]glucose breath test is a simple noninvasive procedure but was not sufficiently robust for an accurate diagnosis of insulin resistance.
Our findings suggest that the test might be helpful in identifying individuals who are not IR, which in turn may contribute to improved diabetes prevention.
American Psychological Association (APA)
Ibarra-Pastrana, Erika& Candia Plata, Maria del Carmen& Alvarez, Gerardo& Valencia, Mauro E.. 2012. Estimation of Insulin Resistance in Mexican Adults by the [13C]Glucose Breath Test Corrected for Endogenous Total CO2 Production. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507164
Modern Language Association (MLA)
Ibarra-Pastrana, Erika…[et al.]. Estimation of Insulin Resistance in Mexican Adults by the [13C]Glucose Breath Test Corrected for Endogenous Total CO2 Production. International Journal of Endocrinology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-507164
American Medical Association (AMA)
Ibarra-Pastrana, Erika& Candia Plata, Maria del Carmen& Alvarez, Gerardo& Valencia, Mauro E.. Estimation of Insulin Resistance in Mexican Adults by the [13C]Glucose Breath Test Corrected for Endogenous Total CO2 Production. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507164