Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans
Joint Authors
Takeyama, Masaharu
Itoh, Hiroki
Suzuki, Yosuke
Tatsuta, Ryosuke
Sato, Yuhki
Source
International Journal of Peptides
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The Japanese herbal medicine (Kampo) Ninjinto has been used for the treatment of gastroenteritis, esogastritis, gastric atony, gastrectasis, vomiting, and anorexia.
The pharmacological effects of Ninjinto on the gastrointestine are due to changes in the levels of gut-regulated peptide, such as motilin, somatostatin, calcitonin gene-related peptide (CGRP), substance P, and vasoactive intestinal polypeptide (VIP).
The release of these peptides is controlled by acetylcholine (ACh) from the preganglionic fibers of the parasympathetic nerve.
Thus, we examined the effects of the selective M1 muscarinic receptor antagonist pirenzepine on the elevation of Ninjinto-induced plasma the area under the plasma gut-regulated peptide concentration-time curve from 0 to 240 min (AUC0→240 min) in humans.
Oral pretreatment with pirenzepine significantly reduced the Ninjinto-induced elevation of plasma motilin and substance P release (AUC0→240 min).
Combined treatment with Ninjinto and pirenzepine significantly increased the release of plasma somatostatin (AUC0→240 min) compared with administration of Ninjinto alone or placebo.
Ninjinto appeared to induce the release of substance P and motilin into plasma mainly through the activation of M1 muscarinic receptors, and pirenzepine may affect the pharmacologic action of Ninjinto by the elevation of plasma substance P, motilin, and somatostatin.
American Psychological Association (APA)
Sato, Yuhki& Itoh, Hiroki& Suzuki, Yosuke& Tatsuta, Ryosuke& Takeyama, Masaharu. 2013. Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans. International Journal of Peptides،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-507167
Modern Language Association (MLA)
Sato, Yuhki…[et al.]. Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans. International Journal of Peptides No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-507167
American Medical Association (AMA)
Sato, Yuhki& Itoh, Hiroki& Suzuki, Yosuke& Tatsuta, Ryosuke& Takeyama, Masaharu. Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans. International Journal of Peptides. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-507167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507167