Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats
Joint Authors
Kirbas, Aynur
Kalkan, Yildiray
Cure, Erkan
Yuce, Suleyman
Aydin, Ibrahim
Yücel, Ahmet Fikret
Yilmaz, Arif
Cumhur Cure, Medine
Tumkaya, Levent
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to investigate the possible protective effects of adalimumab (ADA) on cell damage in rat liver tissue during ischemia/reperfusion (I/R) injury of infrarenal abdominal aorta.
Thirty male Wistar-albino rats were divided into three groups: control, I/R, and I/R+ADA, each group containing 10 animals.
Laparotomy without I/R injury was performed in the control group animals.
Laparotomy in the I/R group was followed by two hours of infrarenal abdominal aortic cross ligation and then two hours of reperfusion.
ADA (50 mg/kg) was administered intraperitoneally as a single dose, to the I/R+ADA group, five days before I/R.
The tumor necrosis factor-alpha (TNF-α) (pg/mg protein) and nitric oxide (NO) (µmol/g protein) levels in the I/R group (430.8 ± 70.1, 8.0 ± 1.1, resp.) were significantly higher than those in the I/R+ADA group (338.0 ± 71.6, P=0.006; 6.3 ± 1.2, P=0.008) and the control group (345.5 ± 53.3, P=0.008; 6.5 ± 1.5, P=0.010, resp.).
I/R causes severe histopathological injury to the liver tissue, but ADA leads to much less histopathological changes.
ADA treatment significantly decreased the severity of liver I/R injury.
ADA pretreatment may have protective effects on experimental liver injury.
American Psychological Association (APA)
Cure, Erkan& Cumhur Cure, Medine& Tumkaya, Levent& Kalkan, Yildiray& Aydin, Ibrahim& Kirbas, Aynur…[et al.]. 2014. Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-507173
Modern Language Association (MLA)
Cure, Erkan…[et al.]. Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-507173
American Medical Association (AMA)
Cure, Erkan& Cumhur Cure, Medine& Tumkaya, Levent& Kalkan, Yildiray& Aydin, Ibrahim& Kirbas, Aynur…[et al.]. Adalimumab Ameliorates Abdominal Aorta Cross Clamping Which Induced Liver Injury in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-507173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507173