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Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging
Joint Authors
Ohlendieck, Kay
O'Connell, Kathleen
Staunton, Lisa
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Mitochondria are of central importance for energy generation in skeletal muscles.
Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging.
Mass spectrometry-based proteomics suggests itself as a convenient large-scale and high-throughput approach to catalogue the mitochondrial protein complement and determine global changes during health and disease.
This paper gives a brief overview of the relatively new field of mitochondrial proteomics and discusses the findings from recent proteomic surveys of mitochondrial elements in aged skeletal muscles.
Changes in the abundance, biochemical activity, subcellular localization, and/or posttranslational modifications in key mitochondrial enzymes might be useful as novel biomarkers of aging.
In the long term, this may advance diagnostic procedures, improve the monitoring of disease progression, help in the testing of side effects due to new drug regimes, and enhance our molecular understanding of age-related muscle degeneration.
American Psychological Association (APA)
Staunton, Lisa& O'Connell, Kathleen& Ohlendieck, Kay. 2011. Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507184
Modern Language Association (MLA)
Staunton, Lisa…[et al.]. Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging. Journal of Aging Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-507184
American Medical Association (AMA)
Staunton, Lisa& O'Connell, Kathleen& Ohlendieck, Kay. Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507184