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Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice
Joint Authors
Wen, Shin
Rideout, Todd C.
Williamson, David L.
Jadhav, Kavita S.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a novel biomarker of LDL clearance and a therapeutic target of cardiovascular disease.
We examined the effects of aerobic exercise training in modulating PCSK9 abundance and hepatic sterol regulation in high-fat-fed C57BL/6 mice.
Mice (n=8) were assigned to a low-fat (LF), high-fat (HF), or an HF with exercise (HF + EX) group for 8 weeks.
The HF + EX group was progressively trained 5 days/week on a motorized treadmill.
The HF + EX group was protected against body weight (BW) gain and diet-induced dyslipidemia compared with the HF group.
The HF + EX group demonstrated an increase in hepatic PCSK9 mRNA (1.9-fold of HF control, P<0.05) and a reduction in plasma PCSK9 (14%) compared with the HF group.
Compared with HF mice, HF + EX mice demonstrated reduced hepatic cholesterol (14%) and increased (P<0.05) nuclear SREBP2 protein (1.8-fold of HF group) and LDLr mRNA (1.4-fold of HF group).
Plasma PCSK9 concentrations correlated positively with plasma non-HDL-C (P=0.01, r=0.84).
Results suggest that treadmill exercise reduces non-HDL cholesterol and differentially modulates hepatic and blood PCSK9 abundance in HF-fed C57BL/6 mice.
American Psychological Association (APA)
Wen, Shin& Jadhav, Kavita S.& Williamson, David L.& Rideout, Todd C.. 2013. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. Journal of Lipids،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-507187
Modern Language Association (MLA)
Wen, Shin…[et al.]. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. Journal of Lipids No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-507187
American Medical Association (AMA)
Wen, Shin& Jadhav, Kavita S.& Williamson, David L.& Rideout, Todd C.. Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-507187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507187