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Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia
Joint Authors
Fujiya, Mikihiro
Ikuta, Katsuya
Kohgo, Yutaka
Shindo, Motohiro
Torimoto, Yoshihiro
Ito, Satoshi
Addo, Lynda
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-12
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Abstract EN
Disseminated intravascular coagulation (DIC) frequently occurs in patients with acute promyelocytic leukemia (APL).
With the induction of therapy in APL using all-trans retinoic acid (ATRA), DIC can be controlled in most cases as ATRA usually shows immediate improvement of the APL.
However, arsenic trioxide (ATO) which has been used for the treatment of relapse in APL patients has shown to take time to suppress APL cells, therefore the control of DIC in APL with ATO treatment is a major problem.
Recently, the recombinant soluble thrombomodulin fragment has received a lot of attention as the novel drug for the treatment of DIC with high efficacy.
Here, we present a relapsed patient with APL in whom DIC was successfully and safely controlled by rTM during treatment with ATO.
American Psychological Association (APA)
Shindo, Motohiro& Ikuta, Katsuya& Addo, Lynda& Ito, Satoshi& Fujiya, Mikihiro& Torimoto, Yoshihiro…[et al.]. 2012. Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-507205
Modern Language Association (MLA)
Shindo, Motohiro…[et al.]. Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia. Case Reports in Hematology No. 2012 (2012), pp.1-2.
https://search.emarefa.net/detail/BIM-507205
American Medical Association (AMA)
Shindo, Motohiro& Ikuta, Katsuya& Addo, Lynda& Ito, Satoshi& Fujiya, Mikihiro& Torimoto, Yoshihiro…[et al.]. Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-507205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507205