Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor Agents
Joint Authors
Li, Tai Hua
Zhang, Chun Li
Fu, Zhan Li
Wang, Rong Fu
Guo, Feng Qin
Niu, Shuang Huan
Yang, Ming
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Five new organogermanium sesquioxides have been synthesized and characterized by elemental analysis and IR spectra.
All the compounds were tested for antitumor activities against KB, HCT, and Bel cells in vitro.
Compound 5 (γ-thiocarbamido propyl germanium sesquioxide) showed excellent antitumor activity, and its inhibition yield to KB, HCT, and Bel cells was 92.9%, 84.9%, and 70.9%, respectively.
A rapid method was described for the labeling compound 5 with T99mc, and the optimum labeling conditions were investigated.
The labeling yield is above 90% in pH 7.0, 20∘C, reaction time greater than 10 minutes, 1 mg of compound 5, and 0.075∼0.1 mg of SnCl2.
The biodistribution of T99mc labeled compound 5 in nude mice bearing human colonic xenografts was studied.
The result showed that the tumor uptakes were 0.73, 0.97, 0.87, and 0.62 ID%/g at 1-hour, 3-hour, 6-hour, and 20-hour postinjection, respectively.
T/NT (the uptake ratio for per gram of tumor over normal tissues) was 18.3 for tumor versus brain and 5.81 for tumor versus muscle at 20-hour postinjection.
The tumor clearance was slow.
The results showed that compound 5 may be developed to be a suitable cancer therapeutic agent.
American Psychological Association (APA)
Zhang, Chun Li& Li, Tai Hua& Niu, Shuang Huan& Wang, Rong Fu& Fu, Zhan Li& Guo, Feng Qin…[et al.]. 2009. Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor Agents. Bioinorganic Chemistry and Applications،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-507249
Modern Language Association (MLA)
Zhang, Chun Li…[et al.]. Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor Agents. Bioinorganic Chemistry and Applications No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-507249
American Medical Association (AMA)
Zhang, Chun Li& Li, Tai Hua& Niu, Shuang Huan& Wang, Rong Fu& Fu, Zhan Li& Guo, Feng Qin…[et al.]. Synthesis and Evaluation of Novel Organogermanium Sesquioxides As Antitumor Agents. Bioinorganic Chemistry and Applications. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-507249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507249