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Altered Gene Expression, Mitochondrial Damage and Oxidative Stress : Converging Routes in Motor Neuron Degeneration
Joint Authors
Rossi, Luisa
Carrì, Maria Teresa
Valle, Cristiana
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Motor neuron diseases (MNDs) are a rather heterogeneous group of diseases, with either sporadic or genetic origin or both, all characterized by the progressive degeneration of motor neurons.
At the cellular level, MNDs share features such as protein misfolding and aggregation, mitochondrial damage and energy deficit, and excitotoxicity and calcium mishandling.
This is particularly well demonstrated in ALS, where both sporadic and familial forms share the same symptoms and pathological phenotype, with a prominent role for mitochondrial damage and resulting oxidative stress.
Based on recent data, however, altered control of gene expression seems to be a most relevant, and previously overlooked, player in MNDs.
Here we discuss which may be the links that make pathways apparently as different as altered gene expression, mitochondrial damage, and oxidative stress converge to generate a similar motoneuron-toxic phenotype.
American Psychological Association (APA)
Rossi, Luisa& Valle, Cristiana& Carrì, Maria Teresa. 2012. Altered Gene Expression, Mitochondrial Damage and Oxidative Stress : Converging Routes in Motor Neuron Degeneration. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-507259
Modern Language Association (MLA)
Rossi, Luisa…[et al.]. Altered Gene Expression, Mitochondrial Damage and Oxidative Stress : Converging Routes in Motor Neuron Degeneration. International Journal of Cell Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-507259
American Medical Association (AMA)
Rossi, Luisa& Valle, Cristiana& Carrì, Maria Teresa. Altered Gene Expression, Mitochondrial Damage and Oxidative Stress : Converging Routes in Motor Neuron Degeneration. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-507259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507259